Overview
| 别名 | Periostin; PN; Osteoblast-specific factor 2; OSF-2 |
| 基因名 | Periostin |
| UniProt ID | Q15063 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 4G1-W7-V4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 93 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | POSTN (periostin) is a matricellular protein that plays diverse roles in both physiological and pathological processes. It is involved in embryonic development, tissue repair, and maintenance of bone and connective tissues. However, abnormal upregulation of POSTN is associated with various diseases, particularly cancer and inflammatory conditions. In cancer, POSTN promotes tumor progression by enhancing cell proliferation, invasion, and metastasis through interactions with integrins and activation of signaling pathways like MAPK and PI3K/AKT. It also contributes to the tumor microenvironment by promoting angiogenesis and fibrosis. In inflammatory diseases such as asthma and fibrosis, POSTN interacts with cytokines and activates pathways like NF-κB, exacerbating inflammation and tissue remodeling. Additionally, POSTN has been implicated in cardiovascular diseases and intervertebral disc degeneration. Its multifaceted roles in disease progression make POSTN a potential biomarker and therapeutic target for various conditions. |
检测原理