Overview
| 别名 | Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products |
| 基因名 | RAGE |
| UniProt ID | Q15109 |
| 反应种属 | Human,Mouse,Rat |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1Y8-F2-C3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 42 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | AGER, or the advanced glycosylation end-product specific receptor, plays a critical role in the relationship between aging and various diseases. This receptor, part of the immunoglobulin superfamily, interacts with advanced glycation end products (AGEs) and other ligands, triggering pro-inflammatory responses that are implicated in age-related conditions such as diabetes, cardiovascular diseases, and neurodegenerative disorders. The accumulation of AGEs in tissues is accelerated in diabetes and contributes to vascular complications, while AGER signaling is linked to the inflammatory processes that exacerbate Alzheimer's disease and other neurodegenerative conditions. Thus, AGER serves as a key mediator in the interplay between aging, inflammation, and disease progression, highlighting its potential as a therapeutic target for age-related diseases. |
检测原理