Overview
| 别名 | Programmed cell death protein 1; Protein PD-1; hPD-1; CD antigen CD279 |
| 基因名 | PD1 |
| UniProt ID | Q15116 |
| 反应种属 | Human,Rat |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6G4-D6-Z6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 31 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Programmed Cell Death 1 (PDCD1), also known as PD-1 or CD279, is a cell surface receptor that plays a critical role in regulating the immune system's response to the body's own cells. It is encoded by the PDCD1 gene and belongs to the immunoglobulin superfamily. PD-1 is primarily expressed on activated T cells, B cells, and macrophages, where it binds to its ligands PD-L1 and PD-L2. By interacting with these ligands, PD-1 negatively regulates immune responses, preventing autoimmune diseases but potentially allowing cancer cells to evade immune attack. PD-1 inhibits T cell receptor signaling, promotes apoptosis of antigen-specific T cells, and reduces apoptosis in regulatory T cells. |
检测原理