Overview
| 别名 | Transcription elongation factor A protein-like 1; TCEA-like protein 1; Nuclear phosphoprotein p21/SIIR; Transcription elongation factor S-II protein-like 1 |
| 基因名 | TCEAL1 |
| UniProt ID | Q15170 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2A6-Q6-H2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 18 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Transcription elongation factor A like 1 (TCEAL1) is a nuclear phosphoprotein belonging to the transcription elongation factor A (SII)-like family. Encoded by an X-linked gene, the protein contains an arginine/serine-rich region, a zinc finger-like motif, and a C-terminal helix-turn-helix-like region. TCEAL1 modulates the transcription of various cellular and viral promoters through protein-protein interactions with transcriptional regulators rather than direct DNA binding. It is broadly expressed, with significant presence in the brain. Clinically, loss-of-function variants in TCEAL1 cause Hijazi-Reis syndrome, an X-linked dominant neurodevelopmental disorder. This syndrome is characterized by developmental delay, intellectual disability, autistic features, and hypotonia, with clinical severity often influenced by X-inactivation patterns in females. |
检测原理