Overview
| 别名 | Mitochondrial fission regulator 1; Chondrocyte protein with a poly-proline region |
| 基因名 | MTFR1 |
| UniProt ID | Q15390 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2N2-T4-D7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 37 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Mitochondrial fission regulator 1 (MTFR1) is a nuclear-encoded protein that localizes to the mitochondria, where it plays a significant role in regulating mitochondrial organization, aerobic respiration, and fission. It is involved in shaping mitochondrial cristae and maintaining respiratory efficiency, likely by coordinating with the core mitochondrial fission and fusion machinery to adjust the mitochondrial network architecture in response to metabolic demands. By influencing mitochondrial morphology and dynamics, MTFR1 ensures that the organelle's structure is optimized for cellular energy production. While perturbations in mitochondrial dynamics are central to various neurodegenerative and metabolic conditions, there are currently no well-established, specific monogenic diseases directly attributed to MTFR1 mutations. It is primarily recognized for its fundamental role in maintaining mitochondrial homeostasis and its potential as a modifier of mitochondrial dysfunction-associated pathologies. |
检测原理