Overview
| 别名 | Corneodesmosin; S protein |
| 基因名 | CDSN |
| UniProt ID | Q15517 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4I1-H3-T6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 51 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Corneodesmosin (CDSN) is a secreted glycoprotein highly enriched in serine and glycine, predominantly localized in corneodesmosomes of the human epidermis and other cornified squamous epithelia, where it plays a crucial role in cell-cell adhesion and the maintenance of skin barrier integrity. The protein is covalently linked to the cornified envelope of corneocytes and is sequentially proteolyzed as corneocytes migrate toward the skin surface, a process essential for proper desquamation and epidermal differentiation. Its N-terminal glycine-rich domain is particularly important for adhesive properties, mediating homophilic interactions that contribute to corneocyte cohesion. Mutations in CDSN, especially nonsense mutations leading to truncated proteins, are associated with rare autosomal dominant hypotrichosis simplex of the scalp, characterized by progressive hair loss, and have been implicated in skin barrier defects and susceptibility to psoriasis. |
检测原理