Overview
| 别名 | Neuronal pentraxin-1; NP1; Neuronal pentraxin I; NP-I |
| 基因名 | NPTX1 |
| UniProt ID | Q15818 |
| 反应种属 | Human,Rat |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1O6-J3-J5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 47 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Neuronal pentraxin 1 (NPTX1) is a secreted glycoprotein exclusively expressed in the nervous system, where it plays a fundamental role in synaptic remodeling and the clustering of AMPA-type glutamate receptors at excitatory synapses. As a member of the long pentraxin family, it facilitates the uptake of synaptic material and mediates the formation of protein complexes essential for synaptic plasticity. In the context of disease, NPTX1 is significantly upregulated in response to amyloid-beta exposure in Alzheimer's disease, where it colocalizes with tau deposits and precedes synaptic loss and neurite damage. Additionally, missense variants in the NPTX1 gene are established causes of autosomal dominant cerebellar ataxia, resulting from endoplasmic reticulum stress and disrupted protein interactions. The protein also responds to hypoxic conditions via HIF-1alpha and has been implicated in the progression of certain squamous cell carcinomas. |
检测原理