Overview
| 别名 | Cystatin-M; Cystatin-6; Cystatin-E |
| 基因名 | CST6 |
| UniProt ID | Q15828 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3U6-A9-X9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 16 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cystatin E/M (CST6) is a cysteine protease inhibitor belonging to the type 2 cystatin family, known for its role in regulating proteolytic activity in various human fluids and tissues. It is encoded by the CST6 gene located on chromosome 11 and is synthesized as a secretory protein with a signal peptide for secretion. CST6 exhibits high affinity for cathepsin L and legumain, playing crucial roles in epidermal cornification and hair follicle maintenance. Loss of CST6 expression has been linked to several diseases, including ectodermal dysplasia and ichthyosis, highlighting its importance in skin and hair development. Furthermore, CST6 is implicated in suppressing osteolytic bone disease in multiple myeloma by inhibiting osteoclast differentiation, underscoring its multifaceted role in disease progression and tissue homeostasis. Overall, CST6 is a significant protein with protective functions that may influence cancer metastasis and other pathological conditions. |
检测原理