Overview
| 别名 | Glutaminyl-peptide cyclotransferase; Glutaminyl cyclase; QC; sQC; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; EC |
| 基因名 | QPCT |
| UniProt ID | Q16769 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3M3-T2-G4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 40 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Glutaminyl-peptide cyclotransferase (QPCT) is an enzyme that catalyzes the intramolecular cyclization of N-terminal glutamine and glutamic acid residues into pyroglutamate residues (pGlu), a posttranslational modification known as pyroglutamylation. This process is crucial for the maturation and stability of various hormones and secretory proteins, such as gonadotropin-releasing hormone (GnRH), thyrotropin-releasing hormone (TRH), and neurotensin. QPCT is encoded by the QPCT gene and is highly expressed in the pituitary, hypothalamus, and other parts of the brain. The enzyme plays a significant role in diseases such as Alzheimer’s disease, where it contributes to the formation of pyroglutamate-modified amyloid peptides, and in cancer, where it is involved in the CD47-SIRPα pathway, affecting immune surveillance. |
检测原理