Overview
| 别名 | Kynurenine--oxoglutarate transaminase 1; Cysteine-S-conjugate beta-lyase; Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; KATI; Kynurenine--oxoglutarate transaminase I |
| 基因名 | KYAT1 |
| UniProt ID | Q16773 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3T4-N9-E2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 47 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Kynurenine aminotransferase 1 (KYAT1) is a cytosolic, pyridoxal 5'-phosphate (PLP)-dependent enzyme that plays a central role in the tryptophan catabolic pathway. It catalyzes the irreversible transamination of L-kynurenine to produce kynurenic acid, a neuroactive metabolite that modulates glutamatergic neurotransmission. Additionally, KYAT1 exhibits beta-lyase activity toward sulfur- and selenium-containing cysteine conjugates, a process that can generate reactive intermediates linked to nephrotoxicity. Structurally, the enzyme functions as a dimer with a well-defined active site containing key catalytic residues such as Lys247 and Glu27. Clinically, KYAT1 is associated with hydroxykynureninuria and schizophrenia, as dysregulation of kynurenic acid homeostasis is implicated in various neuropsychiatric and neurodegenerative conditions. |
检测原理