Overview
| 别名 | Hydroxyacylglutathione hydrolase; mitochondrial; Glyoxalase II; Glx II |
| 基因名 | HAGH |
| UniProt ID | Q16775 |
| 反应种属 | Human,Rat |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8T4-T9-P3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 33 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Hydroxyacylglutathione hydrolase (HAGH), also known as glyoxalase II, is an enzyme encoded by the HAGH gene in humans, located on chromosome 16. It plays a critical role in the detoxification of reactive carbonyl compounds by catalyzing the hydrolysis of S-(2-hydroxyacyl)glutathione to produce glutathione and a 2-hydroxy carboxylate, thus participating in pyruvate metabolism and cellular defense mechanisms against oxidative stress. HAGH is associated with various diseases, particularly neurodegenerative conditions like Alzheimer's disease, where its protein levels have been found to correlate with disease risk in certain genetic backgrounds. Mutations or dysregulation in HAGH activity can contribute to metabolic disorders and complications related to oxidative stress, emphasizing its importance in maintaining cellular homeostasis and preventing disease progression. |
检测原理