Overview
| 别名 | Protein Dok-7; Downstream of tyrosine kinase 7 |
| 基因名 | DOK7 |
| UniProt ID | Q18PE1 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3M5-F2-L6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 53 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Docking protein 7 (DOK7) is an intracellular adaptor protein and a muscle-intrinsic activator of the muscle-specific receptor tyrosine kinase (MuSK). It is essential for neuromuscular synaptogenesis and the clustering of acetylcholine receptors at the neuromuscular junction. DOK7 contains pleckstrin homology and phosphotyrosine-binding domains that facilitate the dimerization and autophosphorylation of MuSK, initiating downstream signaling through adaptors like Crk and CrkL. This process is critical for organizing postsynaptic specializations. Clinically, pathogenic loss-of-function mutations in DOK7 cause congenital myasthenic syndrome type 10, characterized by limb-girdle-predominant muscle weakness and reduced receptor density at the endplates. Severe mutations are also associated with fetal akinesia deformation sequence. |
检测原理