Overview
| 别名 | Zinc finger protein 423; Olf1/EBF-associated zinc finger protein; hOAZ; Smad- and Olf-interacting zinc finger protein |
| 基因名 | ZNF423 |
| UniProt ID | Q2M1K9 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6B6-X9-F3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 144 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Zinc finger protein 423 (ZNF423) is a nuclear transcription factor belonging to the Kruppel-like C2H2 zinc finger family that serves as a critical DNA-binding regulator across multiple signaling pathways. It acts as either a transcriptional activator or repressor to modulate genome maintenance, cellular differentiation, and development. ZNF423 is essential for the DNA damage response, where it relocalizes to nuclear foci to maintain genomic integrity. It also regulates neurogenesis, adipogenesis, and B-cell lymphopoiesis through interactions with retinoic acid receptors and early B-cell factor 1. Mutations in ZNF423 are established causes of Joubert Syndrome and nephronophthisis-14, which are characterized by neuroanatomical defects and renal dysfunction. Additionally, its dysregulation is implicated in various malignancies, including B-precursor acute lymphoblastic leukemia and breast cancer. |
检测原理