Overview
| 别名 | R-spondin-1; Roof plate-specific spondin-1; hRspo1 |
| 基因名 | RSPO1 |
| UniProt ID | Q2MKA7 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5D8-U7-L9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 28 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | R-spondin 1 (RSPO1) is a secreted glycoprotein that plays a critical role in the regulation of the Wnt signaling pathway, particularly by acting as a ligand for the LGR4, LGR5, and LGR6 receptors. This interaction enhances Wnt/β-catenin signaling, which is essential for stem cell maintenance and proliferation across various tissues, including the ovaries and intestines. RSPO1 is structurally characterized by two cysteine-rich furin-like domains and a thrombospondin type 1 domain, which facilitate its binding to both LGR receptors and negative regulators of Wnt signaling like ZNRF3. Dysregulation or mutations in RSPO1 are associated with several diseases, most notably ovarian cancer, where it promotes tumorigenesis by activating Wnt/β-catenin signaling pathways. Additionally, genetic mutations in RSPO1 can lead to developmental disorders such as female-to-male sex reversal in XX individuals and are implicated in various cancers due to their roles in cell proliferation and differentiation. |
检测原理