Overview
| 别名 | Protein mono-ADP-ribosyltransferase PARP6; ADP-ribosyltransferase diphtheria toxin-like 17; ARTD17; Poly [ADP-ribose] polymerase 6; PARP-6 |
| 基因名 | PARP6 |
| UniProt ID | Q2NL67 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7B6-D8-P4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 71 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Poly(ADP-ribose) polymerase family member 6 (PARP6) is a mono-ADP-ribosyltransferase that catalyzes the transfer of a single ADP-ribose unit from NAD+ to specific aspartate or cysteine residues on target proteins. Unlike poly-ADP-ribosylating enzymes, PARP6 is primarily involved in mono-ADP-ribosylation and auto-modification. It localizes to the endoplasmic reticulum and nuclear envelope and is highly expressed in the developing brain, particularly within hippocampal neurons during periods of peak dendritic growth. PARP6 plays an essential role in regulating dendrite morphogenesis and microtubule dynamics, partly through its interaction with microtubule-binding proteins such as MAP2. Clinical relevance is well-established, as mutations or deficiencies in PARP6 are linked to neurodevelopmental disorders including epilepsy, developmental delay, and retinitis pigmentosa 50. |
检测原理