Overview
| 别名 | Zinc finger protein ZXDC; ZXD-like zinc finger protein |
| 基因名 | ZXDC |
| UniProt ID | Q2QGD7 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 2O1-V7-K7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 89 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Zinc finger protein ZXDC (ZXDC) is a transcription factor characterized by its two C2H2-type zinc finger domains, which facilitate DNA binding and transcriptional regulation. It plays a crucial role in the activation of major histocompatibility complex (MHC) class I and II genes by interacting with the class II transactivator (CIITA). ZXDC is involved in various biological processes, including immune responses, cell proliferation, and differentiation. Its expression is regulated by factors such as hypoxia and cytokines, highlighting its role in cellular adaptation to environmental changes. ZXDC has been linked to cancer progression, particularly through its interactions with key proteins like p53 and GSK3β, suggesting its involvement in tumorigenesis. Additionally, dysregulation of ZXDC may contribute to autoimmune diseases, making it a potential target for therapeutic interventions in both cancer and immune-related disorders. |
检测原理