Overview
| 别名 | Zinc finger protein 831 |
| 基因名 | ZNF831 |
| UniProt ID | Q5JPB2 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6B1-Z8-G3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 177 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Zinc finger protein 831 (ZNF831) is a transcriptional regulator characterized by multiple C2H2-type zinc finger domains that facilitate sequence-specific DNA binding. It is expressed in various tissues, including the hippocampus and cerebral cortex, where it typically localizes to the nucleus to modulate gene expression. Functionally, ZNF831 acts as a transcriptional repressor that inhibits STAT3/Bcl2 signaling, thereby promoting apoptosis and enhancing chemosensitivity. In clinical contexts, the downregulation of ZNF831 is well-established in the progression of breast cancer, where its loss leads to reduced apoptotic activity and increased resistance to chemotherapy. Furthermore, specific genetic polymorphisms in ZNF831 have been linked to an increased risk of preeclampsia in patients with gestational diabetes, highlighting its relevance in both oncology and maternal-fetal health. |
检测原理