Overview
| 别名 | UBX domain-containing protein 11; Colorectal tumor-associated antigen COA-1; Socius; UBX domain-containing protein 5 |
| 基因名 | UBXN11 |
| UniProt ID | Q5T124 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3E3-Z9-O3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 57 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; IHC-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | UBX domain protein 11 (UBXN11) is a cytoplasmic protein characterized by a C-terminal UBX domain, which typically mediates interactions with the valosin-containing protein (VCP) complex. It interacts with Rnd family Rho GTPases and G-protein alpha subunits to regulate actin cytoskeleton organization and Rho signaling pathways. Through these interactions, UBXN11 is implicated in the modulation of cell morphology and cytoskeletal dynamics. Additionally, its ubiquitin-binding capacity suggests a role in proteasome-mediated protein degradation. While specific monogenic diseases are not well-established, expression patterns relate UBXN11 to cellular structural integrity and potentially to tumorigenic processes in specific tissues. |
检测原理