Overview
| 别名 | Homeobox protein orthopedia |
| 基因名 | OTP |
| UniProt ID | Q5XKR4 |
| 反应种属 | Human,Mouse |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9F5-N1-H7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 34 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Orthopedia homeobox (OTP) encodes a highly conserved homeodomain protein that functions as a helix-turn-helix transcription factor essential for cell fate specification during embryogenesis. Its expression is highly restricted to the developing forebrain, hindbrain, spinal cord, and hypothalamic neuroendocrine cells. OTP plays a pivotal role in regulating regional identities within the central nervous system and is critical for the differentiation of the hypothalamus. Through sequence-specific DNA binding, it exerts transcriptional control over developmental patterning, sharing structural homology with the orthodenticle and Antennapedia protein families. Its function is vital for the proper organization of the central nervous system and the establishment of neuroendocrine lineages across various species. |
检测原理