Overview
| 别名 | Ral GTPase-activating protein subunit alpha-1; GAP-related-interacting partner to E12; GRIPE; GTPase-activating Rap/Ran-GAP domain-like 1; Tuberin-like protein 1; p240 |
| 基因名 | RALGAPA1 |
| UniProt ID | Q6GYQ0 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6T5-F8-G3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 229 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Ral GTPase activating protein catalytic subunit alpha 1 (RALGAPA1) is a key component of the RalGAP complex, which regulates the activity of RalA and RalB, small GTPases involved in intracellular vesicle trafficking, cell migration, and cytoskeletal dynamics. This protein exhibits GTPase activator activity, converting Ral proteins from their active GTP-bound state to an inactive GDP-bound form. RALGAPA1 functions as the catalytic subunit of the heterodimeric RalGAP complex, alongside a scaffolding β subunit, and plays a crucial role in maintaining cellular signaling balance. Dysregulation of RALGAPA1 can lead to constitutive activation of RalA, disrupting processes such as neuronal polarity and brain development. Mutations or deficiencies in RALGAPA1 are associated with profound neurodevelopmental disabilities, muscular hypotonia, infantile spasms, and feeding abnormalities. Additionally, reduced expression of RALGAPA1 has been linked to enhanced malignancy in cancers like pancreatic ductal adenocarcinoma due to increased migratory and invasive capacities of tumor cells. |
检测原理