Overview
| 别名 | Pyridoxal-dependent decarboxylase domain-containing protein 1 |
| 基因名 | PDXDC1 |
| UniProt ID | Q6P996 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 6T9-D3-I1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 86 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Pyridoxal dependent decarboxylase domain containing 1 (PDXDC1) is a pyridoxal phosphate-dependent enzyme involved in carboxylic acid metabolism and neurotransmitter synthesis. Localized primarily to the Golgi apparatus, it exhibits carboxy-lyase activity and is predicted to facilitate cadherin binding. The protein is expressed across various tissues, with notable concentrations in the cerebral cortex and hippocampus. As a member of the pyridoxal-dependent decarboxylase family, it utilizes vitamin B6 as a cofactor to mediate essential metabolic transitions, although its specific physiological substrates remain to be fully characterized. Clinically, mutations in the PDXDC1 gene are established causes of hereditary hearing loss, specifically Autosomal Recessive Nonsyndromic Deafness 32 (DFNB32) and Autosomal Dominant Nonsyndromic Deafness 77 (DFNA77). |
检测原理