Overview
| 别名 | DCN1-like protein 2; DCNL2; DCUN1 domain-containing protein 2; Defective in cullin neddylation protein 1-like protein 2 |
| 基因名 | DCUN1D2 |
| UniProt ID | Q6PH85 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7V1-F1-Y2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 30 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Defective in cullin neddylation 1 domain containing 2 (DCUN1D2), also known as DCNL2, is a key regulator of the neddylation pathway. It functions by binding to cullin family proteins and promoting their neddylation, a critical post-translational modification that regulates the activity of Cullin-RING ligases. By facilitating this process, DCUN1D2 plays an essential role in protein degradation and cellular homeostasis. The protein is localized to both the cytoplasm and the nucleus, allowing it to coordinate neddylation-dependent signaling across multiple cellular compartments. Its activity is fundamental to the regulation of various protein substrates, although its specific involvement in human disease remains a subject of ongoing investigation. |
检测原理