Overview
| 别名 | Protein disulfide isomerase CRELD2; Cysteine-rich with EGF-like domain protein 2);cysteine rich with EGF like domains 2 |
| 基因名 | CRELD2 |
| UniProt ID | Q6UXH1 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1L9-K1-T6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 38 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | CRELD disulfide isomerase 2 (CRELD2) is a soluble endoplasmic reticulum (ER) glycoprotein that functions as a protein disulfide isomerase (PDI) to aid in protein folding and quality control. Its expression is regulated by the ATF6 pathway and is significantly upregulated during ER stress, where it promotes unfolded protein response (UPR) tolerance. CRELD2 interacts with chaperones such as GRP78/BiP and MANF to enhance the secretory pathway and is itself secreted under stress conditions. Clinically, CRELD2 is linked to various ER stress-related pathologies, including the progression of non-alcoholic fatty liver disease (NAFLD) to NASH, chronic kidney disease, and skeletal disorders such as multiple epiphyseal dysplasia. It also serves as a urinary biomarker for podocyte stress in nephrotic syndrome. |
检测原理