Overview
| 别名 | Protein phosphatase 1 regulatory subunit 21; Coiled-coil domain-containing protein 128; Ferry endosomal RAB5 effector complex subunit 2; Fy-2; KLRAQ motif-containing protein 1 |
| 基因名 | PPP1R21 |
| UniProt ID | Q6ZMI0 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 3S6-L1-B2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 88 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Protein phosphatase 1 regulatory subunit 21 (PPP1R21) is a ubiquitously expressed cytosolic and endosomal protein that serves as a putative regulator of serine/threonine protein phosphatase 1. It acts as a structural hub within the five-subunit FERRY complex, an early endosomal Rab5 effector that links specific mRNAs and ribosomes to Rab5-positive early endosomes to facilitate endosomal mRNA transport and localization. By binding all FERRY subunits, mRNA, and RAB5A, PPP1R21 coordinates endosomal sorting, maturation, and RNA binding. Biallelic loss-of-function variants in PPP1R21 cause an autosomal recessive neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities (NEDHFBA). This condition is characterized by global developmental delay, severe intellectual disability, and impaired endocytic trafficking, supporting the role of PPP1R21 in maintaining cellular proteostasis and vesicular transport. |
检测原理