Overview
| 别名 | Ribonucleoside-diphosphate reductase subunit M2 B; TP53-inducible ribonucleotide reductase M2 B; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2 |
| 基因名 | RRM2B |
| UniProt ID | Q7LG56 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 2X7-M3-R1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 40 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B) is a critical component of the ribonucleotide reductase enzyme, which catalyzes the conversion of ribonucleotides to deoxyribonucleotides for DNA synthesis and repair. RRM2B is induced by p53 and plays a vital role in maintaining mitochondrial DNA (mtDNA) and nuclear DNA integrity, especially in non-proliferating cells. It forms an active complex with RRM1 and exhibits anti-reactive oxygen species (ROS) properties. RRM2B is essential for DNA repair, cell cycle regulation, and mitochondrial homeostasis. Mutations in the RRM2B gene are associated with mitochondrial DNA depletion syndrome (MDDS), a severe condition affecting multiple body systems, characterized by encephalomyopathy, renal tubulopathy, and mtDNA depletion. Additionally, RRM2B mutations have been linked to progressive external ophthalmoplegia and may contribute to gemcitabine resistance in certain cancers. |
检测原理