Overview
| 别名 | E3 ubiquitin-protein ligase SH3RF1; Plenty of SH3s; Protein POSH; RING finger protein 142; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1; SH3 multiple domains protein 2 |
| 基因名 | SH3RF1 |
| UniProt ID | Q7Z6J0 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 3L2-O5-E2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 93 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | SH3RF1 is an E3 ubiquitin ligase that plays important roles in cell death response to apoptotic stimuli and regulation of calcium homeostasis. It is involved in various cellular processes, including the JNK signaling pathway and regulation of NFκB nuclear translocation. SH3RF1 has been implicated in several diseases, particularly cancer and neurodegenerative disorders. In cancer, it has been identified as a regulator of FAT1 cadherin, a protein associated with various cancers. SH3RF1 interacts with FAT1 through its N-terminal SH3 domains and regulates FAT1 protein levels, potentially influencing cancer progression. In neurodegenerative diseases, SH3RF1 has been linked to neuronal migration and regulation of T cell differentiation. Its involvement in immune-related pathways suggests a potential role in the immune component of neurodegeneration, which could have implications for developing new therapeutic strategies or repurposing existing immunotherapies for neurodegenerative diseases. |
检测原理