Overview
| 别名 | Serpin A9; Centerin; Germinal center B-cell-expressed transcript 1 protein |
| 基因名 | GCET1 |
| UniProt ID | Q86WD7 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5Z8-M9-N7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 46 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Serpin family A member 9 (SERPINA9) is a member of the serine protease inhibitor (serpin) family, encoded by the SERPINA9 gene. This secreted glycoprotein (45.9 kDa) contains a conserved serpin domain that facilitates its role in regulating proteolytic enzymes, particularly in the endoplasmic reticulum. SERPINA9 is primarily expressed in B-lymphocytes and lymphoid tissues, where it may inhibit proteases involved in antigen processing or apoptosis. Structural studies reveal its reactive center loop (RCL) mediates target protease inhibition through a conformational "suicide substrate" mechanism typical of serpins. SERPINA9 is implicated in B-cell maturation and germinal center formation. Dysregulation of SERPINA9 has been linked to B-cell malignancies, such as diffuse large B-cell lymphoma (DLBCL), where reduced expression correlates with tumor progression and immune evasion. Additionally, rare mutations may contribute to immunodeficiency disorders by disrupting protease regulation in lymphoid cells. |
检测原理