Overview
| 别名 | Sodium/hydrogen exchanger 9; Na(+)/H(+) exchanger 9; NHE-9; Solute carrier family 9 member 9 |
| 基因名 | SLC9A9 |
| UniProt ID | Q8IVB4 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4W4-Y7-B2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 72 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Solute carrier family 9 member A9 (SLC9A9), also known as sodium/hydrogen exchanger 9 (NHE9), is a membrane protein that regulates the luminal pH of recycling endosomes. It facilitates proton efflux, counteracting the acidity generated by vacuolar ATPase and limiting luminal acidification. SLC9A9 plays a crucial role in maintaining cation homeostasis and is involved in various cellular processes, including endosomal trafficking and signaling. The protein is expressed in multiple tissues, with high levels observed in the brain. Mutations in the SLC9A9 gene have been associated with several neuropsychiatric disorders, including autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD), and epilepsy. Additionally, alterations in SLC9A9 expression and function have been linked to various cancers, such as glioblastoma and esophageal squamous cell carcinoma. |
检测原理