Overview
| 别名 | Tripartite motif-containing protein 59; RING finger protein 104; Tumor suppressor TSBF-1 |
| 基因名 | TRIM59 |
| UniProt ID | Q8IWR1 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6S7-F3-T2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 47 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | TRIM59, a member of the tripartite motif-containing protein family, functions primarily as an E3 ubiquitin ligase and is implicated in various physiological processes, including immune responses and tumor progression. Its expression is associated with several diseases, particularly cancers, where it is often upregulated and linked to poor prognosis. For instance, TRIM59 has been shown to promote tumor cell proliferation and migration by regulating key proteins involved in cell cycle and apoptosis, thereby facilitating cancer development, notably in non-small cell lung cancer and gastric cancer. Additionally, TRIM59 plays a significant role in immune-related diseases; it modulates inflammatory responses and phagocytosis in macrophages, influencing conditions like sepsis. The manipulation of TRIM59 levels presents potential therapeutic avenues for treating immune disorders and malignancies, highlighting its significance in both immune regulation and oncogenesis. |
检测原理