Overview
| 别名 | CD302 antigen; C-type lectin BIMLEC; C-type lectin domain family 13 member A; DEC205-associated C-type lectin 1; Type I transmembrane C-type lectin receptor DCL-1; CD antigen CD302 |
| 基因名 | CD302 |
| UniProt ID | Q8IX05 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7Z2-V6-P5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 26 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | CD302 molecule (CD302), also known as CLEC13A or DCL1, is a type I transmembrane C-type lectin receptor primarily involved in cell adhesion, migration, endocytosis, and phagocytosis. Structurally, it is a 232-amino-acid protein with a 146-amino-acid extracellular domain, a 21-amino-acid transmembrane segment, and a 43-amino-acid cytoplasmic region. The extracellular domain is predicted to contain eight beta strands and two alpha helices, and CD302 is highly conserved across species, sharing 82% sequence identity with its mouse and rat counterparts. Unlike classical C-type lectin receptors, CD302 lacks the amino acid residues necessary for calcium-dependent sugar binding, suggesting a unique ligand recognition mechanism. CD302 is most abundantly expressed in the liver, followed by the lungs, spleen, and myeloid cells such as monocytes, granulocytes, and dendritic cells. Disease relevance includes its identification as an intergenic splice variant forming a fusion protein with DEC-205/CD205 in Hodgkin's lymphoma cell lines, indicating a potential role in hematological malignancies. |
检测原理