Overview
| 别名 | Dynein axonemal assembly factor 8; Dynein axonemal-associated protein 1 |
| 基因名 | DNAAF8 |
| UniProt ID | Q8IYS4 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2W3-S7-Z8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 55 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Dynein axonemal assembly factor 8 (DNAAF8) is a specialized assembly factor essential for the formation of motile cilia. It functions in the cytoplasm of ciliated cells to facilitate the deployment of outer dynein arms (ODA) to the axoneme. DNAAF8 interacts directly with ODA subunits and is predicted to enable dynein complex binding, acting as a scaffold for the assembly of these large microtubule-based motors. By ensuring the proper integration of dynein complexes into the axonemal structure, DNAAF8 plays a critical role in ciliary motility. This process is vital for various physiological functions, including respiratory clearance and embryonic development. Although its primary role is structural and assembly-oriented, its activity is fundamental to the mechanical function of the ciliary apparatus. |
检测原理