Overview
| 别名 | Abnormal spindle-like microcephaly-associated protein; Abnormal spindle protein homolog; Asp homolog |
| 基因名 | ASPM |
| UniProt ID | Q8IZT6 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 9L3-R6-K1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 409 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Assembly factor for spindle microtubules (ASPM) is a large centrosomal protein essential for regulating mitotic spindle dynamics and symmetric cell division during neurogenesis. It contains a microtubule-binding domain that allows it to localize to spindle poles and interact with microtubule minus ends. ASPM coordinates with partners such as calmodulin, katanin, and citron kinase to control spindle assembly, orientation, and cytokinesis. By ensuring proper chromosome segregation and neuroepithelial cleavage plane orientation, it maintains the pool of proliferating neural progenitors. Biallelic mutations in the ASPM gene are the most common cause of primary autosomal recessive microcephaly type 5 (MCPH5), a condition characterized by a significant reduction in brain size due to impaired cerebral cortical neurogenesis. |
检测原理