Overview
| 别名 | Probable E3 ubiquitin-protein ligase TRIML2; RING-type E3 ubiquitin transferase TRIML2; SPRY domain-containing protein 6; Tripartite motif family-like protein 2 |
| 基因名 | TRIML2 |
| UniProt ID | Q8N7C3 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7R5-E8-Y3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 49 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | TRIML2, an E3 ubiquitin ligase, plays a crucial role in various cellular processes, including regulating protein degradation and modulating immune responses. Its dysfunction is linked to several diseases, notably Trichorhinophalangeal Syndrome Type II, characterized by distinct skeletal and facial abnormalities. TRIML2's ubiquitination activity is essential for maintaining cellular homeostasis, and its impairment can lead to pathological conditions, including neurodegenerative diseases. Research indicates that TRIM family proteins, including TRIML2, are involved in critical pathways such as autophagy and apoptosis, emphasizing their potential as therapeutic targets in treating diseases associated with their dysfunction. Understanding the precise mechanisms by which TRIML2 operates could provide insights into its role in disease and pave the way for novel therapeutic strategies. |
检测原理