Overview
| 别名 | Leucine-rich repeat-containing protein 75A; Leucine-rich repeat-containing protein FAM211A |
| 基因名 | LRRC75A |
| UniProt ID | Q8NAA5 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8N1-D4-T5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 37 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Leucine-rich repeat-containing protein 75A (LRRC75A) is a protein that plays a significant role in cellular signaling and has been implicated in various biological processes, including angiogenesis and inflammation. It contains multiple leucine-rich repeats, which are known to mediate protein-protein interactions. Recent studies have highlighted LRRC75A's involvement in the secretion of vascular endothelial growth factor (VEGF) from bone marrow-derived mesenchymal stem cells (BM-MSCs) under ischemic conditions, suggesting its potential as a biomarker for identifying cell subpopulations with angiogenic properties. Additionally, LRRC75A is associated with inflammatory responses; its antisense long non-coding RNA (LRRC75A-AS1) has been shown to regulate tight junction proteins and modulate immune responses in bovine mastitis models. Dysregulation of LRRC75A and its associated pathways can contribute to disease processes, particularly in cancer and inflammatory conditions. |
检测原理