Overview
| 别名 | Draxin; Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; Neucrin |
| 基因名 | DRAXIN |
| UniProt ID | Q8NBI3 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6H1-F5-F8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 38 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Dorsal inhibitory axon guidance protein (DRAXIN) is a secreted, 58 kDa glycosylated protein primarily expressed in the developing brain and spinal cord, where it functions as a chemorepulsive axon guidance molecule essential for neural circuit formation, including the spinal cord commissure, corpus callosum, and thalamocortical projections. Structurally, DRAXIN contains a signal sequence, a mature domain with a cysteine-rich region, and shares similarities with the DKK family of Wnt inhibitors, acting as a Wnt antagonist by binding to LRP6. It interacts with receptors such as DCC and Neo1, influencing axon pathfinding by inhibiting or repelling neurite outgrowth from dorsal spinal cord neurons and regulating the remodeling of midline structures necessary for commissural axon crossing. Disruption of DRAXIN function has been linked to abnormal neural development, particularly affecting the formation of the corpus callosum, which can result in neurodevelopmental disorders due to impaired axon guidance and midline crossing. |
检测原理