Overview
| 别名 | Carbohydrate sulfotransferase 4; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3; GST-3; High endothelial cells N-acetylglucosamine 6-O-sulfotransferase; HEC-GlcNAc6ST; L-selectin ligand sulfotransferase; LSST; N-acetylglucosamine 6-O-sulfotransferase 2; GlcNAc6ST-2; Gn6st-2 |
| 基因名 | CHST4 |
| UniProt ID | Q8NCG5 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6O6-L8-I7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 45 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Carbohydrate sulfotransferase 4 (CHST4) is a Golgi-localized enzyme that belongs to the GlcNAc6ST family and catalyzes the transfer of sulfate to the 6-hydroxyl position of N-acetylglucosamine residues on glycan structures, particularly on ligands of the lymphocyte homing receptor L-selectin. This sulfation is crucial for the proper modification of mucin-type O-glycans, especially core 2-branched structures, and plays a significant role in modulating lymphocyte rolling velocity and the selective recruitment of T and B lymphocytes into peripheral lymph nodes, with a major function in B cell homing. Functionally, CHST4 influences immune cell trafficking and is implicated in immune surveillance. In disease contexts, elevated CHST4 expression has been associated with a favorable prognosis in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC), likely due to its role in recruiting immune cells with tumor-killing activity into the tumor microenvironment, thereby inhibiting tumor progression. |
检测原理