Overview
| 别名 | BEN domain-containing protein 2 |
| 基因名 | BEND2 |
| UniProt ID | Q8NDZ0 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4R6-V9-M2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 87 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | BEN domain-containing protein 2 (BEND2) is an X-linked nuclear protein characterized by two C-terminal BEN domains that mediate DNA and protein interactions involved in transcriptional repression and chromatin remodeling. It regulates gene expression by modulating histone marks like H3K4me3. BEND2 is highly expressed during spermatogenesis, where it is essential for meiotic synapsis and DNA double-strand break repair. In pathology, BEND2 is implicated in CNS tumorigenesis, notably in astroblastoma where MN1-BEND2 fusions function as oncogenic drivers, highlighting its role in chromatin-associated malignancy. |
检测原理