Overview
| 别名 | Aflatoxin B1 aldehyde reductase member 4; AFB1 aldehyde reductase 3; AFB1-AR 3; Aldoketoreductase 7-like |
| 基因名 | AKR7L |
| UniProt ID | Q8NHP1 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 2Y1-A9-M4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 36 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Aldo-keto reductase family 7 like (gene/pseudogene) (AKR7L) is an enzyme belonging to the aldo-keto reductase superfamily that functions as an NADPH-dependent oxidoreductase. It is primarily involved in cellular detoxification processes, specifically targeting reactive aldehydes. A key physiological role of AKR7L is the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) into the non-toxic AFB1 dialcohol. This enzymatic activity provides critical protection to liver tissue by preventing the formation of harmful protein adducts associated with aflatoxin exposure. The gene is located within a cluster of aldo-keto reductase genes on chromosome 1. Its functional role in metabolic detoxification and hepatoprotection is well-documented within the aldo-keto reductase family. |
检测原理