Overview
| 别名 | Interleukin-31 receptor subunit alpha; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; Cytokine receptor-like 3; GLM-R; hGLM-R; Gp130-like monocyte receptor; Gp130-like receptor; ZcytoR17 |
| 基因名 | IL31RA |
| UniProt ID | Q8NI17 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 5O5-D5-A7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 82 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Interleukin 31 receptor A (IL31RA) is a protein encoded by the IL31RA gene, which plays a crucial role in mediating immune responses and inflammation. The protein has a molecular weight of approximately 83.5 kDa and is expressed in various tissues, including epithelial cells and activated monocytes. This protein forms part of the interleukin-31 receptor complex, which includes the oncostatin M receptor (OSMR) and is involved in signaling pathways that promote itching and inflammatory responses, particularly in skin conditions. Mutations in the IL31RA gene have been linked to primary localized cutaneous amyloidosis (PLCA), a condition characterized by the accumulation of amyloid proteins in the skin, leading to severe itching and discomfort. In addition to its role in PLCA, IL31RA has been implicated in asthma and other allergic conditions, where it may contribute to airway hyperresponsiveness and smooth muscle contraction. |
检测原理