Overview
| 别名 | Epidermal growth factor receptor kinase substrate 8-like protein 1; EPS8-like protein 1; Epidermal growth factor receptor pathway substrate 8-related protein 1; EPS8-related protein 1 |
| 基因名 | EPS8L1 |
| UniProt ID | Q8TE68 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3D5-P9-G6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 80 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | EPS8 signaling adaptor L1 (EPS8L1) is a cytoplasmic adaptor protein that modulates Ras signaling and actin cytoskeleton remodeling. As a member of the EPS8 family, it stimulates the guanine nucleotide exchange activity of SOS1, facilitating membrane ruffling and structural changes. EPS8L1 is involved in the maintenance of epidermal and hair follicle barrier structures. Clinically, variants in the EPS8L1 gene are associated with Fetal Akinesia Deformation Sequence 4, a severe congenital neuromuscular disorder. It has also been linked to villous adenocarcinoma and pathways relevant to Fragile X syndrome. These associations underscore the importance of EPS8L1 in developmental signaling and its potential role in tumorigenesis through the regulation of cytoskeletal dynamics. |
检测原理