Overview
| 别名 | Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1 |
| 基因名 | FRS2 |
| UniProt ID | Q8WU20 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 9E2-O1-Q6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 57 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Fibroblast growth factor receptor substrate 2 (FRS2) is an 80 kDa membrane-anchored signal transducing adaptor protein that plays a crucial role in linking activated receptor tyrosine kinases (RTKs) to various downstream signaling pathways, including the MAPK/ERK and PI3K/AKT/mTOR pathways. This protein is encoded by the FRS2 gene in humans and is essential for mediating cellular responses to fibroblast growth factors (FGFs) and nerve growth factor (NGF) receptors. Its properties include the ability to interact with multiple signaling molecules, thereby modulating critical cellular functions like proliferation and differentiation. Dysregulation of FRS2 has been implicated in various diseases, including pigmentation disorders and certain types of cancer, such as prostate cancer. |
检测原理