Overview
| 别名 | SPRY domain-containing protein 4 |
| 基因名 | SPRYD4 |
| UniProt ID | Q8WW59 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 2G2-U1-I1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 23 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | SPRY domain containing 4 (SPRYD4) is a nuclear protein characterized by a conserved C-terminal SPRY domain, which typically mediates protein-protein interactions to regulate signaling pathways and cytoskeletal dynamics. Ubiquitously expressed with high levels in the kidney, brain, and thymus, SPRYD4 localizes to the nucleus, suggesting a role in transcriptional regulation or the stabilization of nuclear protein networks. It is thought to influence cellular processes such as proliferation, migration, and immune modulation, potentially through interactions with immune checkpoints. Clinically, SPRYD4 functions as a tumor suppressor in certain contexts. Its downregulation is specifically observed in cholangiocarcinoma, where low expression levels correlate with poor prognosis, increased cell cycle progression, and enhanced tumor cell migration. |
检测原理