Overview
| 别名 | Radial spoke head 1 homolog; Cancer/testis antigen 79; CT79; Male meiotic metaphase chromosome-associated acidic protein; Meichroacidin; Testis-specific gene A2 protein |
| 基因名 | RSPH1 |
| UniProt ID | Q8WYR4 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6O7-I4-E7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 35 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Radial spoke head component 1 (RSPH1) is a key structural protein found in the axonemal radial spoke complexes of motile cilia and flagella, where it plays a crucial role in regulating ciliary and flagellar motility by contributing to the assembly and stability of the radial spoke head structure. RSPH1 is characterized by multiple membrane occupation and recognition nexus (MORN) repeats, forming elongated curved beta-sheets that interact with other radial spoke proteins through hydrogen bonds, hydrophobic, and electrostatic interactions, thereby locking the core of the radial spoke head in place and extending its surface for optimal function. The protein is predominantly expressed in tissues with motile cilia or flagella, such as the respiratory tract and sperm, and is essential for proper ciliary movement. Mutations in RSPH1 are associated with primary ciliary dyskinesia, a disorder marked by impaired ciliary motility leading to chronic respiratory infections and reduced fertility due to defective sperm flagella. |
检测原理