Overview
| 别名 | TRAF family member-associated NF-kappa-B activator; TRAF-interacting protein; I-TRAF |
| 基因名 | TANK |
| UniProt ID | Q92844 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3Z2-C7-X3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 47 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | TANK is a crucial regulator of NF-κB signaling, playing a significant role in immune responses and inflammation. TANK acts as a negative regulator of NF-κB activation induced by DNA damage, interleukin-1β, and Toll-like receptor stimulation. It forms a complex with MCPIP1 and the deubiquitinase USP10, which facilitates the deubiquitination of TRAF6, thereby inhibiting NF-κB activation. This regulatory function of TANK is essential for maintaining the balance of inflammatory responses and preventing excessive inflammation. In terms of disease associations, TANK has been linked to enhanced aversive emotional processing, which may protect against the development of alcohol drinking behavior. Additionally, the TANK-mediated regulation of NF-κB signaling is crucial in various immune-related processes, including T-cell activation and differentiation, which are implicated in autoimmune diseases and inflammatory disorders. |
检测原理