Overview
| 别名 | Proline-rich AKT1 substrate 1; 40 kDa proline-rich AKT substrate |
| 基因名 | PRAS40 |
| UniProt ID | Q96B36 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1W2-Z2-F3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 27 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:50 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Proline-rich AKT1 substrate 1 (AKT1S1), also known as PRAS40, is a critical regulatory protein that interacts with the AKT signaling pathway, which is essential for cell growth, survival, and metabolism. AKT1S1 functions as a negative regulator of AKT by binding to its phosphorylated form, thereby inhibiting its activity. This protein is characterized by its proline-rich domain, which facilitates interactions with various signaling molecules. Dysregulation of AKT1S1 has been implicated in several diseases, particularly cancer and metabolic disorders. For instance, decreased expression of AKT1S1 has been associated with increased tumorigenesis and poor prognosis in cancers such as breast and prostate cancer, where enhanced AKT activity promotes cell proliferation and survival. Additionally, alterations in AKT1S1 expression have been linked to insulin resistance and type 2 diabetes, highlighting its role in metabolic regulation. |
检测原理