Overview
| 别名 | Repulsive guidance molecule A; RGM domain family member A |
| 基因名 | Repulsive guidance molecule A |
| UniProt ID | Q96B86 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8N1-F6-X9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 49 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Repulsive guidance molecule A (RGMA) is a glycosylphosphatidylinositol (GPI)-anchored protein that plays a significant role in neuronal development and axonal guidance, particularly in the retina. As a member of the repulsive guidance molecule family, RGMA acts as a co-receptor for bone morphogenetic proteins (BMPs), activating the SMAD signaling pathway, which is essential for various cellular processes including cell survival and differentiation. Dysregulation of RGMA has been linked to several diseases, including prostate and breast cancers, where it may inhibit tumor growth and metastasis by modulating cell adhesion and migration. Additionally, alterations in RGMA expression are associated with neurological disorders due to its role in neuronal survival and guidance. |
检测原理