Overview
| 别名 | Kelch domain-containing protein 7B |
| 基因名 | KLHDC7B |
| UniProt ID | Q96G42 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8J6-H4-I5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 63 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Kelch domain containing 7B (KLHDC7B) is a cytoplasmic protein characterized by a C-terminal Kelch beta-propeller domain, which typically facilitates protein-protein interactions. As a member of the Kelch family, it is involved in various cellular processes, including cytoskeletal organization and stress responses. In the context of oncology, KLHDC7B is frequently overexpressed in breast tumors and other malignancies, where it promotes cell proliferation and modulates interferon signaling pathways. Despite its promoter often being hypermethylated, its elevated expression levels serve as a significant prognostic biomarker. KLHDC7B appears to play an oncogenic role by integrating signaling inputs that drive tumor progression, although its precise physiological functions in normal tissue remain a subject of ongoing investigation. |
检测原理