Overview
| 别名 | SH2 domain-containing adapter protein D |
| 基因名 | SHD |
| UniProt ID | Q96IW2 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6V2-H9-H3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 38 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Src homology 2 domain containing transforming protein D (SHD) is an intracellular adaptor protein characterized by an SH2 domain that mediates phosphotyrosine residue binding. Located on chromosome 19p13.3, SHD functions as a scaffold to assemble signaling complexes downstream of receptor and non-receptor tyrosine kinases. It is predicted to participate in tyrosine kinase-mediated signaling pathways by recognizing phosphorylated tyrosines, thereby facilitating protein-protein interactions rather than exhibiting enzymatic activity. Clinically, pathogenic variants in SHD are associated with ectodermal dysplasia 12, characterized by defective development of sweat glands, hair, and teeth, as well as autosomal recessive spinocerebellar ataxia 14, a neurodegenerative disorder featuring progressive gait and limb ataxia. |
检测原理