Overview
| 别名 | Cilia- and flagella-associated protein 418 |
| 基因名 | CFAP418 |
| UniProt ID | Q96NL8 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3H9-J3-R1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 23 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cilia and flagella associated protein 418 (CFAP418) is a ubiquitously expressed protein with high mRNA levels in the brain, heart, and retina, and is predicted to localize primarily in the cytoplasm and cytosol, including photoreceptor inner segments where it may play a role in photoreceptor cell morphogenesis. CFAP418 is implicated in processes such as Kupffer's vesicle development and melanosome transport, suggesting a role in ciliary and flagellar structure or function. Expression data indicate its presence across multiple tissues, particularly those with specialized ciliary structures, supporting its involvement in ciliary biology. Clinically, mutations in the human CFAP418 gene have been associated with Bardet-Biedl syndrome 21 and cone-rod dystrophy 16, linking its dysfunction to ciliopathies and retinal degeneration. |
检测原理