Overview
| 别名 | Nectin-4; Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4; Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4] |
| 基因名 | NECTIN4 |
| UniProt ID | Q96NY8 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8K7-G4-C3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 55 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Nectin cell adhesion molecule 4 (NECTIN4) is a calcium-independent type I transmembrane protein that mediates cell-cell junction formation through homophilic and heterophilic interactions. It consists of three extracellular immunoglobulin-like domains and a cytoplasmic tail that interacts with Afadin to regulate actin cytoskeleton remodeling and cell migration. NECTIN4 is highly overexpressed in various malignancies, including breast, lung, urothelial, and ovarian cancers, where it promotes tumor growth, angiogenesis, and metastasis via the PI3K/AKT signaling pathway. Under hypoxic conditions, a soluble form of NECTIN4 is shed and interacts with integrin-β4 on endothelial cells to further enhance angiogenesis. Additionally, its intracellular region can translocate to the nucleus to facilitate DNA repair. Clinically, elevated NECTIN4 expression is a well-established biomarker for poor prognosis and reduced survival across multiple cancer types. |
检测原理